Merge a Nuke Mutations Update Guide – Get Mutations

The latest Merge a Nuke update introduces Mutations, giving you another reason to keep spawning and merging Nukes instead of simply chasing the next upgrade. Nukes can now appear with special visual effects and Mutation bonuses, and it’s even possible for one Nuke to have multiple Mutations at once.

The update also adds two small but very useful features: you can destroy unwanted Nukes to make room for new ones and lock valuable Nukes so you don’t accidentally merge or destroy them.

If you’re wondering how Mutations work and how to start collecting them, here’s everything added in the update.

Mutations are special effects that can appear on your Nukes.

When a Nuke receives one, you’ll notice a different visual effect around it. Picking up the Nuke provides more information about the Mutation, including its name, effect, and what it does.

Discovered Mutations are also recorded in the new Mutations Index, giving you a collection to gradually complete.

Nukes appear to have a chance of receiving a Mutation when they’re spawned, with Mutations also potentially being associated with the merging process.

That makes repeatedly cycling through your Nukes an important part of Mutation hunting.

Rather than keeping every ordinary Nuke sitting around, you can now remove ones you don’t need and wait for replacements to spawn.

When you finally get a mutated Nuke, its special effect should make it easier to identify.

Open the Index and select the newly added Mutations section.

Mutations are divided into several rarity categories:

This gives Mutation hunting its own progression system. Common Mutations should naturally be easier to encounter, while the higher-rarity categories are the ones you’ll likely spend more time trying to discover.

Your collected Mutations will automatically appear in the Index, making it easy to see which ones you’ve already found.

Yes. A Nuke isn’t necessarily limited to a single Mutation.

It’s possible to have multiple Mutations applied to the same Nuke.

When this happens, you’ll see multiple Mutation icons associated with it. This means finding one Mutation doesn’t necessarily mean that Nuke is finished—it can potentially become even more valuable if additional effects are added.

Because of that, be especially careful when merging or destroying Nukes that already have good Mutations.

Pick up the Nuke and hold it in your hand.

The game will display information about its Mutation, including the effect it received and what that Mutation actually does.

This is worth checking before you merge or destroy anything. Some Mutation effects can be visually obvious, but checking the information directly removes any guesswork.

Once you’ve discovered the Mutation, it should also be registered in your Mutation Index.

The update adds a new Destroy Nuke button.

Select an unwanted Nuke and use the Destroy option. The Nuke will explode and be removed, allowing another Nuke to eventually take its place.

This is particularly useful for Mutation farming.

Previously, an unwanted Nuke could simply take up space until you dealt with it through normal progression. Now you can deliberately cycle through Nukes while searching for ones that spawn with Mutations.

Alongside the Destroy option is a new Lock icon.

Locking a Nuke protects it from being accidentally used.

Most importantly, a locked Nuke cannot be merged. Locking it also prevents you from using the Destroy option on that Nuke.

This is one of the first things you should do after finding a particularly valuable mutated Nuke.

Instead of risking an accidental merge while you’re moving through your Nukes quickly, lock the one you want to keep and continue working with everything else.

Mutation farming appears to revolve around getting as many new Nuke opportunities as possible.

Keep spawning and merging Nukes normally, but inspect them for Mutation effects as they appear. If you have unwanted Nukes taking up space, use the new Destroy function to remove them and allow fresh Nukes to spawn.

When you find a Mutation you want to keep, immediately lock that Nuke.

Then continue cycling through your remaining Nukes.

Since Nukes can hold multiple Mutations, don’t automatically discard an already-mutated Nuke just because you’ve registered its Mutation in the Index. It may still have the potential to receive additional effects.

Despite the new Mutation progression system, this update doesn’t add additional Rebirths.

The maximum remains at:

10 Rebirths

So if you’ve already reached Rebirth 10, you won’t have another Rebirth tier to grind in this particular update.

Instead, completing the Mutation Index and finding Nukes with desirable or multiple Mutations gives endgame players something new to work toward.